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Jumat, 10 September 2010

Free Ebook Paint Shop Pro 8 For Dummies

Free Ebook Paint Shop Pro 8 For Dummies

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Paint Shop Pro 8 For Dummies


Paint Shop Pro 8 For Dummies


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Paint Shop Pro 8 For Dummies

From the Back Cover

Enhance colors, erase mistakes, and improve your image Create professional-looking graphics for print or the Web, easily and economically Okay, you’ve got some great pictures – and maybe some not-so-great ones. With this handy guide and Paint Shop Pro 8, you can make them magnificent, inexpensively! Find out how to capture those images and repair, retouch, create cool effects, add text, animate images, make prints – well, you get the picture. The Dummies Way Explanations in plain English "Get in, get out" information Icons and other navigational aids Tear-out cheat sheet Top ten lists A dash of humor and fun

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About the Author

David Kay is a writer, engineer, artist, and the author of five For Dummies books. William "The Ferrett" Steinmetz is a freelance Webmaster and editor who helms StarCityGames.com.

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Product details

Series: For Dummies

Paperback: 400 pages

Publisher: For Dummies; 1 edition (May 30, 2003)

Language: English

ISBN-10: 0764524402

ISBN-13: 978-0764524400

Product Dimensions:

7.4 x 0.8 x 9.2 inches

Shipping Weight: 1.4 pounds

Average Customer Review:

4.2 out of 5 stars

17 customer reviews

Amazon Best Sellers Rank:

#561,566 in Books (See Top 100 in Books)

I love all the "Dummies books I have ever read, they are all very well written, and the subject is always written in a way to keep you reading. Love them all if you need a learn or brush up on anything don't ever be afraid or look down on these books, they have much more info than most books the average person will ever read.

I bought this for my sister. It is working fine for her.

Learned a lot. Easy to follow. Good resource book.

As I usually do when purchasing a new program, I buy several books on the subject. I find something different in each book. This one disappointed me in that I am totally new to PSP8 and find that actual screen shots very helpful.

Perfect for people/photo amateurs like I. Very, very helpful.

I've used Paint Shop Pro 8 for only a couple of months before I bought this book. I was seldom interested in using it for advanced stuff - commonly called "bells and whistles". I was only using it for simple stuff. I just wanted to know why some so-called "tools" and stuff "disappear" just when I need them, especially the Font selection and font size tool when I want to insert plain text. Two short paragraphs on page 315 do not help. And other paragraphs which mention how to use the "View" options to select various tools, palettes and such did not help either; I already knew about those. And "starting from scratch", so to speak, and following the detailed instructions on adding text, did not help either. What a waste of my money, not to mention the added aggravation.

Good information not just for Dummies.

I like the way this book is written. Often the writers of manuals write as if you already understand the subject to begin with. You might know what all the words mean, but put them together and it's like Greek to me. But this book makes it understandable and sometimes even amusing. Good job.

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Selasa, 31 Agustus 2010

Free Ebook Rick Steves Snapshot Copenhagen & the Best of Denmark, by Rick Steves

Free Ebook Rick Steves Snapshot Copenhagen & the Best of Denmark, by Rick Steves

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Rick Steves Snapshot Copenhagen & the Best of Denmark, by Rick Steves

Rick Steves Snapshot Copenhagen & the Best of Denmark, by Rick Steves


Rick Steves Snapshot Copenhagen & the Best of Denmark, by Rick Steves


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Rick Steves Snapshot Copenhagen & the Best of Denmark, by Rick Steves

About the Author

Rick Steves has spent 100 days every year since 1973 exploring Europe. Rick produces a public television series (Rick Steves Europe), a public radio show (Travel with Rick Steves), and an app and podcast (Rick Steves Audio Europe); writes a bestselling series of guidebooks and a nationally syndicated newspaper column; organizes guided tours that take thousands of travelers to Europe annually; and offers an information-packed website (RickSteves.com). With the help of his hardworking staff of 80 at Rick Steves Europe, Inc.—in Edmonds, Washington, just north of Seattle—Rick's mission is to make European travel fun, affordable, and culturally broadening for Americans.

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Product details

Series: Rick Steves Snapshot

Paperback: 216 pages

Publisher: Avalon Travel Publishing; 3 edition (September 22, 2015)

Language: English

ISBN-10: 1631210602

ISBN-13: 978-1631210600

Product Dimensions:

4.5 x 0.5 x 8 inches

Shipping Weight: 12.6 ounces

Average Customer Review:

4.5 out of 5 stars

43 customer reviews

Amazon Best Sellers Rank:

#386,590 in Books (See Top 100 in Books)

Great guide book that made the trip easy. I have noticed that I have slightly different preferences than Rick Steves and often needed more time in the museums than Rick recommends. I love that Rick's guide books have a walking tour of the city to get a flavor for the city and see some interesting (mainly) outdoor sights.

Love Rick Steves books. I used to purchase Fommer's for my trips and it was very informative, however, once you take one of Rick's books you never go back. Very informative, up to date information, always includes his honest opinion about his recommendations. The maps and the walks are also very helpful. His books are not only informative but also very entertaining reading. Love them all. Thanks Rick.

Worth its cost just for the one day itinerary. In Copenhagen for a long layover, and covered so much ground using Rick's itinerary.

This was really useful when touring Odense and Copenhagen. The recommended walking tour of Copenhagen led us to sites we wouldn't otherwise have seen (the astronomical clock inside of City Hall) or appreciated (the Weather Ladies) or the former whipping post. We left it in Copenhagen for the next tourists to enjoy.

I guess I should have known by the title "snapshot", but this is actually just the Copenhagen section of the Scandanavia book of his, published separately. I have that full book already, so for me this was a waste of money. It's good material, though, just that I thought it would be expanded content (usually the more specific the subject, the more detailed the content...?), which it isn't at all.Anyway, it would have been nice to make that clear in the description so I would have known before ordering it (it's on the back cover of the book so in a store I would have seen it right away).

Rick Steeves book on Copenhagen is very easy to read and gives lots of information on how to get the best out of a stay in the city. I would recommend it to anyone planning on traveling to Copenhagen to buy this book.

Rick Steves Copenhagen helped me plan a successful trip to Copenhagen. Clear directions, instructions, maps were helpful and the book gave a nice narrative on points of interest.

This would be better if it were a pocket edition. It is literally just a piece of his bigger book- no map inserts and it's all black and white.

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Selasa, 24 Agustus 2010

Free Ebook Gray Day: My Undercover Mission to Expose America's First Cyber Spy

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Audible Audiobook

Listening Length: 9 hours and 42 minutes

Program Type: Audiobook

Version: Unabridged

Publisher: Random House Audio

Scheduled Audible.com Release Date: March 26, 2019

Language: English, English

ASIN: B07NZVQ62K

Amazon Best Sellers Rank:

I had never heard of the spy Robert Hanssen . I thought it would be an interesting read and it was interesting. The book blurb presents this story as a 'tension packed stew'. I felt I was reading more of a procedural. As a young FBI agent, Eric O'Neill is put in a position ( a need to know position ) to help bring down suspected spy Robert Hanssen. Robert Hanssen was a decades long FBI employee,, in various high positions which allowed him access to information he sold to the Russians. The case takes place during 2001 so this book was a long time coming, and the author states he was finally given permission to write his side of the story. As a young agent the author is set up to be the sole employee of a newly created department or section and Robert Hanssen is his boss.I did feel the tension and stress that the younger Eric O'Neill was under with trying to cope with a new marriage, law school and his increasingly stressful job. He's fed information as the case progresses and his tasks become increasingly dangerous - trying to steal his bosses keys, stealing his palm pilot, getting close to his boss etc. It's a struggle to handle this heavy load as well as the lies he had to tell his new wife. That all came through loud and clear and I kept wishing the poor guy would give himself a break and take a leave from law school at least!It's interesting/amusing/nostalgic to recall the early days of computers and technology being integrated into our daily lives. I well remember Palm Pilots and how awesome they were, which you have to chuckle at today but that was the beginning. Today it seems so incredibly naive that the FBI would create computer databases with no real protection against access. That's how it was then though, and Robert Hanssen was very intelligent with computing and both the power and weak points of computerizing data. He masterfully stole classified information and sold it to the Russians for 22 years. Given how the author describes some former antics of the spy it's also amazing to me that such a whack job ( several incidents were revealed which should have gotten the guy fired right away) was able to keep getting these good assignments which provided him access to classified data. Thankfully, AFTER 2001 the FBI learned a tough lesson that that their employees have to be monitored also. Hard to believe, that seemed like a huge "duh" to me but that's how it was.Even given all the above the novel reads more like a procedural with regards to the case. I'm happy that Mr O'Neill was able to write the book as I don't feel he received adequate credit for all he did to stop and catch Hanssen.What was disturbing to read was the extent and level of expertise that the Russians have used to spy on the USA. I think most everyone, especially today, knows that most governments spy on each other and try to influence politics to their advantage. Again I'm just surprised that the FBI took so long to beef up cybersecurity.Ending the story the author discusses more about Russian, Chinese and North Korean cyber spying in the USA and the importance of cybersecurity, including computers that are linked together in a network are all vulnerable if one computer is infected. The FBI has instituted a security education and awareness training program to spot possible illegal access of information. But it still comes down to people.

I found this to be much more like reading a memoir than a case study, so depending on how interested you are in learning about the author himself, rather than just Robert Hanssen, this can be a pro or a con. I, personally, found the writing style to be typical of other books written by government agents who worked on a notable case. Not special, not bad. Overall, IMHO, worth a read if you are interested in the life of an FBI agent or in the Robert Hanssen case.But that’s JustMe.

Although written by the agent who cracked the Hanssen case, this book doesn't add to those already out there. The writing is awkward and contradictory at times when the author is trying to fill in irrelevant details around his life at the time.

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Kamis, 12 Agustus 2010

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Product details

File Size: 17302 KB

Print Length: 338 pages

Publisher: Morgan Kaufmann; 1 edition (September 11, 2013)

Publication Date: September 11, 2013

Sold by: Amazon Digital Services LLC

Language: English

ASIN: B00FDU4ZY4

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I have a few thousand hours of experience working with CUDA Fortran and can say that this book is perfect for the advance and beginner CUDA Fortran programmers alike. The concepts are laid out succinctly and clearly. The book includes codes written for tests and performance feedback related to each topic with detailed discussion that will be very helpful for learning CUDA Fortran and fully understanding the CUDA GPU architectures. The book is helpful also in that it includes methods for using CUDA cards up through the Tesla K20. This was important for me as the Tesla K20 has, up until the past couple of months, had poor literature describing best practices and how to take advantage of the card's capabilities. The biggest offering this book brings to the table is that you won't have to waste time searching around online trying to find half-baked information in forums and/or papers.I also recommend "The CUDA Handbook" as another resource to understand programming with GPUs.

Very useful! The approach is very didactic!

Very good book!

I utilized this book for my first explicit FEM code with cuda fortran(Tesla K20c). With easy-to-understand descriptions, I could understand many concepts in detail. The important thing is I have been able to write cuda fortran code and accelerate my original sequential CPU code. I hope more and more practical topics such as how to accelerate Conjugate Gradient method used in the various numerical simulator would be covered in the next revision of this book!! I love this book! Great thanks to the author!

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Rabu, 28 Juli 2010

Ebook Free The Gargoyle, by Andrew Davidson

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Amazon.com Review

Product Description An extraordinary debut novel of love that survives the fires of hell and transcends the boundaries of time. The narrator of The Gargoyle is a very contemporary cynic, physically beautiful and sexually adept, who dwells in the moral vacuum that is modern life. As the book opens, he is driving along a dark road when he is distracted by what seems to be a flight of arrows. He crashes into a ravine and suffers horrible burns over much of his body. As he recovers in a burn ward, undergoing the tortures of the damned, he awaits the day when he can leave the hospital and commit carefully planned suicide—for he is now a monster in appearance as well as in soul. A beautiful and compelling, but clearly unhinged, sculptress of gargoyles by the name of Marianne Engel appears at the foot of his bed and insists that they were once lovers in medieval Germany. In her telling, he was a badly injured mercenary and she was a nun and scribe in the famed monastery of Engelthal who nursed him back to health. As she spins their tale in Scheherazade fashion and relates equally mesmerizing stories of deathless love in Japan, Iceland, Italy, and England, he finds himself drawn back to life—and, finally, in love. He is released into Marianne's care and takes up residence in her huge stone house. But all is not well. For one thing, the pull of his past sins becomes ever more powerful as the morphine he is prescribed becomes ever more addictive. For another, Marianne receives word from God that she has only twenty-seven sculptures left to complete—and her time on earth will be finished. Already an international literary sensation, The Gargoyle is an Inferno for our time. It will have you believing in the impossible. Andrew Davidson Talks About Becoming a Writer Some of what follows is true. When I was about seven, I had a turtle named Stripe. I decided, because I liked my turtle and Jacques Cousteau, that I wanted to be a marine biologist. This ambition lasted until I was ten years old, when I spent a year gazing into the abyss, hoping that the abyss would not gaze back at me. At eleven, I longed for a master to teach me the secrets of the ninja, but the teacher did not appear; this probably means that as a student I was not ready. As I entered my teens, I set my heart upon becoming a professional hockey player. On weekend nights, the final game at the local arena ended around 10 p.m. but the icemaker was unable to leave the building until about midnight, as he had to clean the dressing rooms and do maintenance. I bribed him with presents of Aqua Velva aftershave to let me play alone on the rink until he headed home. Despite my devotion, I never developed the skills to make it off the small-town rink and into the big leagues. My dream shattered, at sixteen I started to spend more time writing. I began by changing the lyrics to Doors songs. I rewrote "Break On Through" so that it became "Live to Die": "Soldier in the forest / dodging bullets thick / only took one / to make him cry / All of us just live to die." Clearly, writing was my future. I soon realized that, since I still had no authorial voice of my own, I should at least imitate better poets than Jim Morrison. Soon I was word-raping Leonard Cohen, e.e. cummings, Sylvia Plath, William Blake, and John Milton. After writing much abusively derivative poetry, I moved onto stage plays written in a mockery of the style of Tennessee Williams, which also didn’t work out so well. Next, I tried to put baby in a corner, until it was explained to me that nobody puts baby in a corner. Following this, I produced short stories that would have been much better if they were much shorter. Then, screenplays that even Alan Smithee wouldn’t direct. Somewhere along the way, I managed to get a degree in English Literature; this was strange, as I thought I was studying cardiology. Undaunted, off to Vancouver Film School I went, but naturally not to study film. Instead, I took the new media course, because there was this thing called the internet that was just taking off. I also spent a fair amount of time using digital editing software for video and audio. An example project: I slowed down the final movement to Beethoven’s Ninth Symphony, looped it backwards, put in a heavy drumbeat, and end up with a funeral dirge. "Ode to Joy"? I think not. "Ode to Bleakness" is more like it; I was very deep, and showed it by destroying joy. After this course finished, I had tens of thousands of dollars of student debt, and could no longer avoid getting a job. I soon discovered, in no uncertain terms, that work is no fun. I stuck it out for as long as I could, which was way less than a lifetime. As my thirtieth birthday approached, I became incredibly aware that I had never lived abroad, so I moved to Japan. I had no idea if I would like Japan, but I vowed to stick it out for a year. I did, and then another year, and another, and another, and another. In the beginning, I worked as a kind of substitute teacher of English, covering stints in classrooms that needed a temporary instructor. I lived in fifteen different cities during my first two years, traveling from the northern island of Hokkaido all the way down to the southern island of Okinawa. It was a great introduction to the country, but eventually the constant relocation became too much. I got a job in a Tokyo office, writing English lessons for Japanese learners on the internet. I lived in the big city for three years, and loved it: hooray for sushi, hooray for sumo, and hooray for cartoon mascots. While in Japan, I entertained myself by writing and, having already mangled poetry, short stories, stage plays and screenplays, I thought it was time to give a novel a shot. A strange thing happened: I found that I don’t write like other people when it comes to novels—or at least, none of which I know. It’s true that I’ve read comparisons of my novel to a number of other books—The Name of the Rose, The English Patient, The Shadow of the Wind—but I haven’t read any of them. (To my great shame, really, and I suppose I should. Since they are my supposed influences, I should become familiar with them. I’ll appear more intelligent in interviews.) I liked writing The Gargoyle, and I think I’ll write another novel. If I can, I’ll make up new characters and a new plot. That’s my plan.

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From Publishers Weekly

Starred Review. At the start of Davidson's powerful debut, the unnamed narrator, a coke-addled pornographer, drives his car off a mountain road in a part of the country that's never specified. During his painful recovery from horrific burns suffered in the crash, the narrator plots to end his life after his release from the hospital. When a schizophrenic fellow patient, Marianne Engel, begins to visit him and describe her memories of their love affair in medieval Germany, the narrator is at first skeptical, but grows less so. Eventually, he abandons his elaborate suicide plan and envisions a life with Engel, a sculptress specializing in gargoyles. Davidson, in addition to making his flawed protagonist fully sympathetic, blends convincing historical detail with deeply felt emotion in both Engel's recollections of her past life with the narrator and her moving accounts of tragic love. Once launched into this intense tale of unconventional romance, few readers will want to put it down. (Aug.) Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

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Product details

Hardcover: 480 pages

Publisher: Doubleday (August 5, 2008)

Language: English

ISBN-10: 9780385524940

ISBN-13: 978-0385524940

ASIN: 0385524943

Product Dimensions:

6.5 x 1.3 x 9.5 inches

Shipping Weight: 1.8 pounds (View shipping rates and policies)

Average Customer Review:

4.5 out of 5 stars

593 customer reviews

Amazon Best Sellers Rank:

#234,937 in Books (See Top 100 in Books)

BEST BOOK EVER WRITTEN! I buy copies in bulk so I may gift it to others. Its this insane tale of a guy who is basically a terrible person. He gets into the most elegantly written hell fire of a car wreck and is no longer viewing himself as human after his 'member' is gone. While he is being terrible to all the endearing hospital staff a lady from the psych ward comes over and insists on telling him about her 7 hearts and how he is hers. All of his other drug addled mates abandon him rather quickly so for the sake of some company (any company) he listens to her 7 stories over the span of the book, each one thrusting you into past life regressions and even Dantes Inferno. READ THIS BOOK! Its perfect. I am not the only person passing out copies to everyone. Its life changing, rich, historical, dramatic, exciting, and terrifying. Andrew Davidson is doing a disservice to humanity by not putting out another book out, because after you read this you'll be desperate for more.

This was a fascinating book, weaving what would seem to be incongruous stories into a seamless, well written and incredibly well researched novel. What a mix of genres: Realistic fiction, historical fiction, tragedy, romance, magic realism, suspense, mystery, drama. Realistic, imaginative, intelligent and thought provoking. Memorable. Loved it.

Amazing Book!!! Yasmine Yousaf (Krewella) Favorite Book. If she recommended the book. It must be amazing! Fictional story, but the authors only book Andrew Davidson has ever written. It kind of feels like it could of been a biography of His life. Amazing work!!! A must read for you to believe what i am talking about. Long story short. No spoilers trust me. The very first part of the book. Maybe 40 pages in it gets really specific and detailed on what is happening to this one character. But, the story is definitely a page turner for sure.

I read this book in 2 days I just couldn't put it down it was not what I expected it's not actually about any gargoyles it's about this man's journey through life he was living one lifestyle ended up living a different lifestyle there's a little bit of a fantasy in there but it's mostly pretty straightforward about how this guy transforms his life after a tragedy. There is a bit of a horror aspect to it so you have to kind of like some of the darker stuff as well it was right up my alley and I loved it

This is a story that takes place in the present. The main character is a guy who was reluctantly raised by various people because his mother died when he was young. He was very bright and found comfort in books. At at an early age he was on his own and made his living in the adult film industry.The book starts out with his having a car accident. In the hospital he meets Marianne who may or may not be schizophrenic. She tells him that she has known him through several reincarnations. The book is filled with her stories of his past life. He doesn't believe her, but she gives him the will to live and stays with him during his long recovery.Eventually part of him does believe her. I would have preferred if he totally believed her, but she is the first and only person he has ever loved.I'm not big on love stories, but this was a wonderful book. I highly recommend it.

I did not expect this book to be as good as it is. How it was written like a diary and how honest the character was.I liked how the author was very meticulous with the burn treatment. It was factual and it really helped me understand the severity of the character's situation and what he was going through. And it wasn't just the physical side, the mental and emotional side was also very nicely written that it coincided with the whole ordeal he was going through."Accidents ambush the unsuspecting, often violently, just like love."I liked the odd love story of this book. How it's unadulterated love that Marianne felt and worked to it until the end. It was painful reading her struggle rather than the burn part which was quite odd but good because it was unexpected and gave it a sort of twist."I do not believe in any God that considers love to be a sin.""I am not a hero in soul and never will be, but I am better than I was. Or so I tell myself; and for now, that is enough.""If you cannot love the pain, you can at least love the lesson it teaches.""All the while, I'm composing in my mind. These pages that you have now read, most of them originated at my lonely command post at the edge of the world where the earth falls into the sea. I have spent much time there, in this grand empty space between memory and desire, creating this cracked empire of sentences in which I now live."

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Minggu, 25 Juli 2010

Ebook Free The Best Fake Book Ever -- C Instruments (2nd Ed.) -- 3rd Ed. Now Available ISBN# 0634034243

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The Best Fake Book Ever -- C Instruments (2nd Ed.) -- 3rd Ed. Now Available ISBN# 0634034243

For keyboard, vocal, guitar, and all "C" instruments.

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Product details

Series: Fake Books

Plastic Comb: 864 pages

Publisher: Hal Leonard Corp; 2nd edition (February 1991)

Language: English

ISBN-10: 0793500214

ISBN-13: 978-0793500215

Product Dimensions:

1.2 x 9.5 x 12 inches

Shipping Weight: 5.1 pounds

Average Customer Review:

4.0 out of 5 stars

9 customer reviews

Amazon Best Sellers Rank:

#1,417,987 in Books (See Top 100 in Books)

This Fake Book has been added to my library. I have many books C, Bb, Eb, - Buying used books save me a lot of money.I use the books with my combo and they work great

my husband loves this book. he doesn't "read" music so this is exactly what he needs

Product as described

Sure, the authors of the book aren't being modest, but they aren't lying. Other books I have looked at contain maybe one good song and a bunch that nobody has heard of. Every page in this book has a recognizable title and they all are contained in the index in the beginning (which lists them alphabetically and by genre). The words and notes are easy to read and the pages stay open because of its strong binding. I believe, and thus I am writing, that this is the best fake book and it is good for beginners and experts.

Book not very good shape. Cover falling off. Not described as having this problem.

I am using this book now for programs I give for nursing homes. The only thing I disliked was that it fell apart. However, I now have it in 3 notebooks and it is working out very well. I will use this book a lot.

I consider this book to be an outstanding value for the money. No matter what your age, you will find some songs that you know. The book is BIG, and that is both a plus and a minus. What I did was to split the book into three parts, but first copy the table of contents so you can place it in each section. It's just to big to thumb through and to set on the piano while you are playing. The plus side of this is that you have hundreds and hundreds of songs to choose from.I have several fake books, and I use this one more than any of them. Look over the index of songs before you buy, and see if there are enough songs that you know. I'm sure you will find enough songs to keep you busy for many months. I use this for piano, so I can't address how useful this is to guitar players and others.Remember, this is a book that uses chords. You play chords with the left, and the melody with the right hand. There is no bass clef.

My hair stood when I played "Just the way you are" with Billy Joels original chords. If you were born in the 60s/70s you will love this book. It contains songs like Honesty, Dont let the sun do down on me, Unchained melody, You decorated my life. If you aint familiar with the song all you have to do is download it from the net, copy it on a floppy and play it on your keyboard. Then you can choose an appropriate beat and bang away. The book is very heavy...litreally.

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The Best Fake Book Ever -- C Instruments (2nd Ed.) -- 3rd Ed. Now Available ISBN# 0634034243 PDF

Rabu, 07 Juli 2010

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Product details

File Size: 2968 KB

Print Length: 638 pages

Publisher: Academic Press; 1 edition (October 25, 2011)

Publication Date: October 25, 2011

Sold by: Amazon Digital Services LLC

Language: English

ASIN: B006CFZSEU

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Amazon Best Sellers Rank:

#1,668,937 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

Hi,I have received my book. I will recommend this book to anyone who just enters clinical trial industry. Thank you!

The following is a quotation from a review that was published in Journal of Clinical Research Best Practices, Vol. 8, Sept. 2012. The author of this review is Norman M. Goldfarb.The published review is as follows, and I quote:"Clinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines, is a solid guide to designing clinical trials for medical scientists, especially those working in oncology, immune disease, and infectious disease. The statistical chapters are brief and include very few formulae. Three chapters address quality-of-life topics. In addition to the core material, the book also includes chapters on some ancillary topics like patents and package inserts."[My comment on the above writing is that the chapter on STATISTICS contains seventeen (17) mathematical formulas.]The published review by Dr. Goldfarb also states, "Essential reading for clinical research professionals."The published review also reveals this:"The section on study designs discusses and provides diagrams for 17 schemas. The following text illustrates the book's fairly technical style:FORWARDS SEQUENCE AND REVERSE SEQUENCE -- THE PUHALLA SCHEMA.The clinical trial of Puhalla et al. (38) contains two arms (Fig. 2.8). Subjects in the first arm received drugs in this order: D followed by AC. In detail, subjects received docetaxel on the first day of each cycle, for 4 cycles, where each cycle was 14 days long. This was followed by doxorubicin (an anthracycline drug) plus cyclophosphamide, on the first day of each cycle, for 4 cycles. Each cycle was 2 weeks long.Now, this is about the second arm. Subjects in the second arm received drugs in the reverse order, that is, AC followed by D. The investigators chose a 2-arm study design, where each arm was the reverse of the other, because it was not possible to predict which order would provide the better outcome.The type of trial design, where one arm uses a "forward sequence" of two drugs, and where another arm uses the "reverse sequence" of the two drugs, sometimes finds a basis in the mechanism of action of certain drugs. The following specifically concerns chemotherapy involving paclitaxel and gemcitabine. As explained by Paccagnella et al. (39) for a clinical trial on lung cancer, "[s]everal reports have shown that the sequence of administration of gemcitabine and paclitaxel may also affect the efficacy of this combination chemotherapy, since paclitaxel increases the concentration of active metabolite of gemcitabine (dFdCTP) when administered first."To repeat, the above review was written by Norman M. Goldfarb. The complete version of Dr. Goldfarb's review was published in J. Clin. Res. Best Practices, Vol. 8, Sept. 2012.

This is the most comprehensive book on clinical trials I've seen so far.Touches all key areas of clinical trials conduct; I very much enjoyed (yes, I do enjoy learning about the work I love!) the elaboration on Biomarkers and Endpoints. This manual is useful even for experienced professionals, has chapters to be used as a reference and presents new information as well. Extremely well organized, easy to read and informative, a must for any clinical research professional.

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